Relocate

If your open to relocating for a new job you most definitely will open new doors.  Some places have more opportunities than others.  Some cities might have certain industries or companies in your expertise.  This isn't for everyone but for those able to easily pick up and move it can certainly help in your job search by being flexible.  If you relocate for a job be sure to ask the employer if they offer relocation incentives such as moving costs or temporary housing.